Drmtlgy Peptide Night Cream Review

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A good moisturizer is key to any skincare routine, but despite the plethora of options available on the market, finding a cream that truly works is no easy task, so it’s easy to create quite the collection of moisturizers while testing them out. One that I’ve been using recently is the Drmtlgy Peptide Night Cream, a nourishing cream focused on reversing and preventing signs of aging while strengthening the skin’s protective barrier. So if you’re wondering if this night cream is truly worth all the hype, keep on reading for my Drmtlgy Peptide Night Cream review.

About Drmtlgy

Drmtlgy is a great skincare brand that sells a wide range of skincare products. Their main focus is on acne and anti-aging skincare, but most of their products will work for any skin type or skin concern.

Drmtlgy Mission Statement:

At DRMTLGY we value two things: It can’t be bad for you, and it has to work! We focus on creating high-end skin care using the purest, safest, most clinically-proven active ingredients available. Our goal is to be the industry leader of quality premium skin care and customer satisfaction.

For me, Drmtlgy hits all the checkmarks when looking for a good skincare brand: affordable, good ingredients and none of the bad stuff. They are also cruelty-free which is a huge plus in my book! Looking at the other products Drmtlgy offers, they stick to their word when it comes to formulating skincare products that work.

All of their products are packed with well-researched, effective ingredients. So good, in fact, they could be considered medical grade, but without the price tag. Although their products are priced on the higher end, it’s a steal when it comes to the quality of product you are getting. 

About Drmtlgy Peptide Night Cream

The Drmtlgy Peptide Night Cream is a luxurious, rich cream that’s perfect for dry, sensitive skin types. It has a unique blend of 6 different peptides which help to target all signs of aging, while powerful ingredients like ceramides and cholesterol work to strengthen your skin’s barrier.

The moisturizer is cruelty-free, fragrance-free vegan, oil-free and paraben free.

After I fell in love with the Drmtlgy Needle-less Serum, I knew I had to give this night cream a try. Let’s dive in and take a closer look at the ingredients and benefits of this moisturizer.

Drmtlgy Peptide Night Cream Ingredients

Water/Aqua/Eau, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii (Shea) Butter, Caprylic/Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Ceramide EOP, Ceramide AP, Palmitoyl Tetrapeptide-7, Ceramide NP, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl, Hydroxythreonine, Tocopherol, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium EDTA, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride


Glycerin is a superstar ingredient that helps to moisturize and soothe the skin. It works by attracting water to the skin and keeping it there, hydrating and moisturizing the skin. It’s known to be one of the best ingredients for dry skin types.

Shea Butter

Shea butter is one of the most common butters found in skincare products, and for good reason. It’s packed with beneficial fatty acids, vitamins and nutrients that help to soften, smooth, and protect the skin. It can help moisturize, nourish, soothe and protect skin, which is why it’s one of the best ingredients for dry skin.

Caprylic/​Capric Triglyceride

A type of emollient that helps to nourish, soften and smooth skin. It’s one of the most common emollients used in skincare because it’s so well tolerated and beneficial for the skin.

Cetyl Alcohol

Cetyl alcohol is a fatty alcohol that helps to soften and moisturize the skin. It acts as an emollient, which helps to soften and smooth skin, leaving it feeling hydrated and nourished.


Dimethicone is one of the most common types of silicones used in skincare and cosmetic products. Not only does it give the product a nice slip and silky feel, but it also creates a protective barrier to lock in moisture in the skin and keep out any irritants. It can also help to smooth the skin, blur pores and fill in fine lines.


This is where this moisturizer really shines! It contains a blend of 6 peptides:

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-5

Palmitoyl Tetrapeptide-7

Trifluoroacetyl Tripeptide-2

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

These peptides work together to boost collagen production in the skin, which helps to reduce the appearance of fine lines and wrinkles. They can also help to improve skin tone and texture, reducing signs of aging like sagging and dullness.

Palmitoyl Tripeptide 1 makes up part of the famous Matrixyl 3000 peptide complex, which is known to be one of the most effective anti-aging ingredients on the market. It helps to boost collagen production in the skin and reduce signs of aging like wrinkles, fine lines, and sagging.

Palmitoyl Tripeptide-5 has also been shown to help minimize large pores, promote wound healing, smooth skin texture and visibly improve skin elasticity and firmness.

Trifluoroacetyl Tripeptide-2 has been shown to help with sagging skin, loss of elasticity, and fine lines.

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate (I can’t pronounce it either) has been shown to help stimulate the production of hyaluronic acid in the skin, which helps to keep it soft, supple and plump. It also works to reduce inflammation, making it ideal for irritated or sensitive skin.

All in all, this moisturizer is packed with powerful peptides that can help to revitalize and rejuvenate the skin, minimizing the signs of aging for smooth, supple, youthful-looking skin.


This moisturizer contains the ideal blend of Ceramide NP, Ceramide EOP and Ceramide AP. These three ceramides work together to help strengthen the skin’s natural barrier and keep moisture in while keeping irritants out. Ceramides are an essential part of our skin’s protective barrier.

As we age, our skin’s natural ceramide levels begin to decline, which can lead to dryness and irritation. This moisturizer contains the perfect blend of these three essential ceramides to help promote healthy, hydrated skin.


A really nice addition to this moisturizer, Phytosphingosine is a lipid that’s naturally found in the skin. It helps to restore the skin’s natural barrier, protecting it from external irritants and keeping moisture sealed in. It’s also been shown to have anti-bacterial properties.


Cholesterol is another very important part of our skin’s barrier. Along with fatty acids and ceramides, cholesterol keeps your skin barrier strong, nourished and moisturized.


Allantoin is a superstar ingredient that helps to soothe sensitive, irritated skin as well as promote wound healing.

Tocopherol (Vitamin E) 

Vitamin E is a powerful antioxidant that helps to protect the skin from free radical damage and reduce signs of premature aging. It can also help to soothe and moisturize dry, sensitive skin.

Drmtlgy Peptide Night Cream Benefits

Nourishes skin – With a blend of ceramides, vitamin e, allantoin and shea butter, this cream is packed with vitamins, minerals and nutrients that help to moisturize, nourish and protect your skin overnight

Strengthens skin barrier – With a blend of ceramides, cholesterol and phytosphingosine, this night cream helps to replenish the skin’s natural barrier to prevent moisture loss while keeping irritants out

Firms and tightens – The blend of peptides help to firm skin by stimulating collagen and elastin production. It can help reduce sagging skin and volume loss associated with aging

Stimulates collagen – The peptides in this cream help to stimulate collagen production, reducing the appearance of fine lines and wrinkles and prevent the natural loss of collagen and elastin

Smooths and brightens – Peptides can help to smooth skin texture, fade pigmentation and help to brighten for skin that appears more youthful and glowing

Prevents aging – With a powerful blend of antioxidants and peptides, this night cream works to prevent the signs of aging like wrinkles and fine lines. It can help your skin look smoother, firmer and more youthful

Drmtlgy Peptide Night Cream Review – My Thoughts


The ingredients list for this night cream is packed with amazing, skin-nourishing ingredients like ceramides, vitamin e, allantoin and shea butter. I love that it contains peptides as well to help firm the skin and stimulate collagen production. Peptides are often under-hyped when it comes to their anti-aging properties!

This cream has all of the good stuff and none of the bad – it’s free of any irritating ingredients like alcohols, fragrance or essential oils. It’s perfect for sensitive skin and is gentle enough to use every night without causing any irritation or breakouts.

It actually has a pretty minimal ingredients list compared to some moisturizers. Although it’s packed with some really powerful, skin-nourishing ingredients, I’m glad that this cream doesn’t contain any fillers or other unnecessary additives like a lot of moisturizers do. This makes it a great choice for those with sensitive or reactive skin types.


The Drmtlgy Peptide Night Cream retails for $46 for 2oz of product. Although it may seem pricey, a little goes a long way with this cream. It’s also significantly less than the popular Drunk Elephant Protini Polypeptide Cream.


review of drmtlgy peptide night cream

The night cream comes in a sleek jar. The packaging is simple but elegant, and the gold accents make it feel a bit luxurious. It also comes with a handy scoop, which keeps the cream clean and prevents any contamination from dipping your fingers in. I personally love all of Drmtlgy’s packaging – it’s sleek, easy to store and isn’t bulky or excessive.


drmtlgy peptide night cream up close texture

The texture of this cream is truly divine – it’s creamy, velvety and feels super luxurious on the skin. It’s thick enough to provide intense hydration, but it sinks in quickly and doesn’t leave your skin feeling greasy or oily. I’ve never tried a cream that feels quite like this.

drmtlgy peptide night cream review

It leaves your skin feeling nourished but never heavy or greasy, even if you use it during the day. It sinks in quickly and doesn’t leave a film or have that sticky feeling that a lot of heavier moisturizers do. And since it’s so thick, you don’t need to use a lot of product at all, which means one jar will last you quite a while.

texture of drmtlgy peptide night cream


This cream is fragrance-free and does not have any noticeable scent

drmtlgy peptide night cream benefits


I’ve been using this cream for about 6 months now and it’s become my daily night cream! I can’t go a day without it. Now that it’s getting cooler where I live, I also use it during the day and it wears very well under makeup and doesn’t cause my skin to get greasy.

My skin feels softer and smoother since i’ve started using this night cream. I also love how it reduces the appearance of fine lines and wrinkles – it’s also helped to brighten my skin and fade some of my pigmentation.

If I find that I’ve over-exfoliated or used a new product that my skin didn’t agree with, this cream always seems to help calm my skin down and make it feel more comfortable. Overall, I absolutely love this cream and would definitely recommend it to anyone looking for an effective peptide-based night cream.

Overall Thoughts

  • Barrier repairing – This moisturizer is formulated with glycerin, ceramides, cholesterol, shea butter and Phytosphingosine which all work together to strengthen and protect the skin barrier so your skin is healthy, hydrated and moisturized
  • Anti-aging– Packed with a blend of 6 peptides, this night cream targets all signs of aging – from sagging skin, loss of collagen to fine lines and wrinkles, this cream can help it all
  • Nourishing – Glycerin, shea butter, allantoin and Vitamin E hydrate, moisturize and nourish skin with vitamins, minerals and nutrients for skin that’s left healthy and glowing

Overall, I think the Drmtlgy Peptide Night Cream is one of the best night creams on the market today. It contains some really powerful, skin-nourishing ingredients that really work to hydrate and rejuvenate your skin. Not to mention all of the anti-aging benefits of this night cream! It’s powerful enough to reverse signs of aging, but also prevent signs of aging like fine lines, wrinkles and sagging skin.

It’s gentle enough for sensitive or reactive skin and has a lovely texture that makes it enjoyable to use every night. I would definitely recommend this cream for dry, sensitive or normal skin. I think it would be a bit too heavy for oily or combination skin.

Drmtlgy Peptide Night Cream Review Wrap Up

Drmtlgy Peptide Night Cream

This rich cream helps to target signs of aging, strengthen the skin barrier and keep skin moisturized but never greasy

  • Treats signs of aging
  • Brightens skin
  • Prevents signs of aging
  • Strengthens skin barrier
  • Moisturizes & nourishes

Overall, this is a powerful anti-aging moisturizer that’s packed with nourishing and anti-aging ingredients. It’s one of the best night creams on the market and is a great choice for anyone looking for the perfect night cream to help with signs of aging. The Drmtlgy Peptide Night Cream is a fantastic option for anyone looking to fight signs of aging and hydrate their skin. Its luxurious texture feels amazing on your skin, while its powerful anti-aging ingredients work to rejuvenate and protect your skin.

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